Recent Publications by the Principal Investigators

Lohman AW, Leskov IL, Butcher JT, Johnstone SR, Stokes TA, Begandt D, DeLalio LJ, Best AK, Penuaela S, Leitinger N, Ravichandran KS, Stokes KY, Isakson BE. 2015. Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation. Nat Commun. 6:7965. (PMCID: PMC4824045)

Adamson SE, Meher, AK, Chiu, YH, Sandilos JK, Oberholtzer NP, Walker NN, Hargett SR, Seaman SA, Peirce-Cottler SM, Isakson BE, McNamara CA, Keller SR, Harris TE, Bayliss DA, Leitinger N. 2015. Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes. Mol Metab. 4(9)610-8. (PMCID: PMC4563021)

Billaud M, Chiu YH, Lohman AW, Parpaite T, Butcher JT, Mutchler SM, DeLalio LJ, Artamonov MV, Sandilos JK, Best AK, Somlyo AV, Thompson RJ, Le TH, Ravichandran KS, Bayliss DA, Isakson BE. 2015. A molecular signature in the pannexin1 intracellular loop confers channel activation by the a1 adrenoreceptor in smooth muscle cells. Sci Signal. 8(364). (PMCID: PMC4358815)

Desai BN, Leitinger N. 2014. Purinergic and calcium signaling in macrophage function and plasticity. Front Immunol. 5:580.  (PMCID:PMC4245916)

Adamson SE, Leitinger N. 2014. The role of pannexin1 in the induction and resolution of inflammation. FEBS Lett. 588(8):1416-22.  (PMCID: PMC4060616)

Lohman AW, Isakson BE. 2014. Differentiating connexin hemichannels and pannexin channels in cellular ATP release. FEBS Lett. 588(8):1379-88.  (PMCID: PMC3996918)

Poon KI., Chiu YH, Armstrong AJ, Kinchen JM, Juncadella IJ, Bayliss DA, and Ravichandran, KS. 2014. Unexpected link between an antibiotic, pannexin channels and apoptosis. Nature. 507(7492):329-34.  (PMCID: PMC4078991)

Isakson BE, Thompson RJ. 2014. Pannexin-1 as a potentiator of ligand-gated receptor signaling. Channels (Austin). 8(2):118-23.  (PMCID: PMC4048300)

Penuela S, Lohman AW, Lai W, Gyenis L, Litchfield DW, Isakson BE, Laird DW. 2014. Diverse post-translational modifications of the pannexin family of channel-forming proteins. Channels (Austin). 8(2):124-30.  (PMCID: PMC4048301)

Chiu, YH, Ravichandran KS, and Bayliss, DA. 2014. Intrinsic properites and regulation of Pannexin 1 channel. Channels (Austin). 8(2):1-7. (PMCID: PMC4048298)

Sandilos JK, Bayliss DA. 2012. Physiological mechanisms for the modulation of pannexin 1 channel activity. J. Physiol. 590(pt 24):6257-66. (PMCID: PMC3533187)

Lohman AW, Weaver JL, Billaud M, Sandilos JK, Griffiths R, Straub AC, Penuela S, Leitinger N, Laird DW, Bayliss DA, Isakson BE. 2012. S-nitrosylation inhibits pannexin 1 channel function. J Biol Chem. 287(47):39602-12. (PMCID: PMC3501028)

Lohman AW, Billaud M, Isakson BE. 2012. Mechanisms of ATP release and signalling in the blood vessel wall. Cardiovasc Res. 95(3):269-80.  (PMCID: PMC3400358)

Looft-Wilson RC, Billaud M, Johnstone SR, Straub AC, Isakson BE. 2012. Interaction between nitric oxide signaling and gap junctions: effects on vascular function. Biochim Biophys Acta. 1818(8):1895-902.  (PMCID: PMC3229654)

Johnstone SR, Billaud M, Lohman AW, Taddeo EP, Isakson BE. 2012. Posttranslational modifications in connexins and pannexins. J Membr Biol. 245(5-6):319-32.  (PMCID: PMC3954810)

Billaud M, Sandilos JK, Isakson BE. 2012. Pannexin 1 in the regulation of vascular tone. Trends Cardiovasc Med. 22(3):68-72.  (PMCID: PMC34555115)

Sandilos JK, Chiu YH, Chekeni FB, Armstrong AJ, Walk SF, Ravichandran KS, Bayliss DA. 2012. Pannexin 1, an ATP release channel, is activated by caspase cleavage of its pore-associated C terminal autoinhibitory region. J. Biol Chem. 287:11303-11. (PMCID: PMC3322839)

Lohman AW, Billaud M, Straub AC, Johnstone SR, Best AK, Lee M, Barr K, Penuela S, Laird DW, Isakson BE. 2012. Expression of pannexin isoforms in the systemic murine arterial network. J Vasc Res. 49(5):405-16.  (PMCID: PMC3482510)

Billaud M, Lohman AW, Straub AC, Looft-Wilson R, Johnstone SR, Araj CA, Best AK, Chekeni FB, Ravichandran KS, Penuela S, Laird DW, Isakson BE. 2011. Pannexin1 regulates α1-adrenergic receptor- mediated vasoconstriction. Circulation Research. 109(1):80-5. (PMCID: PMC3135971)

Chekeni, F, Elliott MR, Sandilos J, Walk SF, Kinchen JM, Lazarowski E, Armstrong A, Penuela S, Laird D, Salvesen G, Isakson BE, Bayliss DA, and Ravichandran KS. 2010. Pannexin 1 channels regulate ‘find-me’ signal release and membrane permeability during apoptosis. Nature. 467:863-867. (PMCID: PMC3006164)

Kadl A, Meher AK, Sharma PR, Lee MY, Doran AC, Johnstone SR, Elliott MR, Gruber F, Han J, Chen W, Kensler T, Ravichandran KS, Isakson BE, Wamhoff BR, Leitinger N. 2011. Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2. Circulation Research. 107(6):737-46. (PMCID: PMC2941538)

Elliott, MR., Chekeni F, Trampont P, Lazarowski E, Kadl A, Walk SF, Park D, Woodson R, Ostankovich M, Sharma P, Harden TK, Lysiak JJ, Leitinger N, and Ravichandran KS. 2009. Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance. Nature 61(7261): 282-86. (PMCID: PMC2851546).